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- Title
Polyphenols of Melaleuca quinquenervia leaves pharmacological studies of grandinin.
- Authors
F. A. Moharram; M. S. Marzouk; S. A. A. El-Toumy; A. A. E. Ahmed; E. A. Aboutabl
- Abstract
Four polyphenolic acid derivatives and three ellagitannins were isolated from the leaves of Melaleuca quinquenervia (Clav.) S. T. Blake for the first time. Their structures were elucidated as gallic acid (1), ellagic acid (2), 3-O-methylellagic acid (3), 3,4,3'-tri-O-methylellagic acid (4), 2,3-O-hexahydroxydiphenoyl-(α/β)-D-4C1-glucopyranose (5), castalin (6) and grandinin (7) on the basis of chemical, mass spectrometric (-ve ESI-MS) and spectroscopic (UV, 1H-, 13C NMR, 1H,1H-, 1H,13C-COSY, 1H,1H-TOCSY and HMBC) analyses. Grandinin (the major compound) showed radical scavenging properties by its reaction with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical [EC50 = 4.3 ± 0.3 µg mL-1]. It was found to be relatively nontoxic in mice [LD50 = 316 mg Kg-1 b.wt.]. It exhibited a significant dose-dependent (3570 mg Kg-1) hypoglycemic effect by signific-antly reducing blood glucose level in basal condition and after heavy glucose load in normal mice. Moreover, it reduced the elevated blood glucose level in STZ-induced diabetic mice. In addition, grandinin reduced the elevated blood urea nitrogen and serum lipid peroxides in STZ-induced diabetic mice. Copyright © 2003 John Wiley & Sons, Ltd.
- Subjects
PLANT extracts; MELALEUCA quinquenervia; POLYPHENOLS; LEAVES; GALLIC acid
- Publication
Phytotherapy Research, 2003, Vol 17, Issue 7, p767
- ISSN
0951-418X
- Publication type
Article
- DOI
10.1002/ptr.1214