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- Title
Clinical significance of oxidative stress markers as angioinvasion and metastasis indicators in papillary thyroid cancer.
- Authors
Buczyńska, Angelika; Sidorkiewicz, Iwona; Kościuszko, Maria; Adamska, Agnieszka; Siewko, Katarzyna; Dzięcioł, Janusz; Szumowski, Piotr; Myśliwiec, Janusz; Szelachowska, Małgorzata; Popławska-Kita, Anna; Krętowski, Adam
- Abstract
Angioinvasion remains the important prognostic feature in papillary thyroid cancer (PTC) patients. Literature data indicates several markers that may be associated with oxidative stress and/or angioinvasion. Therefore, we assessed the utility of selected parameters in angioinvasion and metastasis screening in serum of PTC patients. Serum antioxidant capacity (TAC) and sirtuin 3 (SIRT3) levels were decreased (all p < 0.05) and both DNA/RNA oxidative stress damage products (DNA/RNA OSDP) and malondialdehyde (MDA) levels were increased in PTC patients with angioinvasion and metastasis (study group) when compared with PTC patients without these features (all p < 0.01). The highest screening utility in differentiation between angioinvasion and metastasis presence and absence in PTC patients was presented for DNA/RNA OSDP (AUC = 0.71), SIRT3 (AUC = 0.70), and TAC (AUC = 0.67) (all p < 0.05). Our study suggests that peripheral concentration of oxidative stress markers could be useful as angioinvasion and metastasis indicator in PTC patients.
- Subjects
THYROGLOBULIN; OXIDATIVE stress; THYROID cancer; METASTASIS; OXIDANT status; MEDICAL screening
- Publication
Scientific Reports, 2023, Vol 13, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-023-40898-9