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- Title
Activity of chequerboard combinations of ceftaroline and NXL104 versus β-lactamase-producing Enterobacteriaceae.
- Authors
Mushtaq, S.; Warner, M.; Williams, G.; Critchley, I.; Livermore, D. M.
- Abstract
Background: Ceftaroline is a novel oxyimino-cephalosporin, strongly active against methicillin-resistant staphylococci and pneumococci. It is active against Enterobacteriaceae too, but is labile to common β-lactamases, including AmpC and extended-spectrum types. To counteract these enzymes, ceftaroline is also being developed combined with NXL104, a β-lactamase inhibitor.
- Subjects
CEPHALOSPORINS; BETA lactamases; ENTEROBACTERIACEAE; BETA lactam antibiotics; ANTIBACTERIAL agents; ENZYMES
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2010, Vol 65, Issue 7, p1428
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkq161