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- Title
Influence of concomitant prednisolone on trimethoprim-associated hyperkalaemia.
- Authors
Mohan, Sumit; Jaitly, Manasvi; Pogue, Velvie A.; Jen-Tse Cheng
- Abstract
Objectives: Trimethoprim–sulfamethoxazole may cause hyperkalaemia by the amiloride-like effect of trimethoprim on sodium channels in the distal nephron. Hyperkalaemia usually occurs after 7–10 days and has been reported in 20%–50% of patients receiving trimethoprim–sulfamethoxazole. Patients with Pneumocystis jiroveci pneumonia and severe hypoxaemia benefit from the use of prednisolone as an adjuvant to trimethoprim–sulfamethoxazole. The addition of prednisolone may lower the incidence of trimethoprim-related hyperkalaemia due, in part, to its mineralocorticoid activity. We studied the effect of concomitant prednisolone on trimethoprim-related hyperkalaemia.
- Subjects
TRIMETHOPRIM; POTASSIUM in the body; AMILORIDE; KIDNEY tubules; SODIUM channels; SULFAMETHOXAZOLE; THERAPEUTICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2009, Vol 64, Issue 4, p850
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkp280