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- Title
Stem cell treatment of dystrophic dogs.
- Authors
Bretag, Allan H.
- Abstract
Arising from: M. Sampaolesi et al. 444, 574–579 (2006); Sampaolesi et al. replyHuman muscular dystrophies are devastating and incurable inherited diseases. Hopes of progress towards therapy of muscular dystrophies were aroused when Sampaolesi et al. reported “extensive recovery of dystrophin expression, normal muscle...function”, and “remarkable clinical amelioration” in golden retriever muscular dystrophy dogs treated with ‘mesoangioblasts’. Here I re-examine their results, showing how their assessments might be flawed and their conclusions overstated. Further studies will be required to evaluate fully the clinical potential of this work.
- Subjects
DYSTROPHY; ETIOLOGY of diseases; DISEASE research; DYSTROPHIN genes; CYTOSKELETAL proteins; MEMBRANE proteins; ANIMAL health; DOGS; GENETIC disorders
- Publication
Nature, 2007, Vol 450, Issue 7173, pE23
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature06437