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- Title
In Vitro and In Vivo Biocompatibility of Boron/Nitrogen Co-Doped Carbon Nano-Onions.
- Authors
d'Amora, Marta; Camisasca, Adalberto; Arenal, Raul; Giordani, Silvia
- Abstract
Boron/nitrogen, co-doped, carbon nano-onions (BN-CNOs) have recently shown great promise as catalysts for the oxygen reduction reaction, due to the improved electronic properties imparted by the dopant atoms; however, the interactions of BN-CNOs with biological systems have not yet been explored. In this study, we examined the toxicological profiles of BN-CNOs and oxidized BN-CNOs (oxi-BN-CNOs) in vitro in both healthy and cancer cell lines, as well as on the embryonic stages of zebrafish (Danio rerio) in vivo. The cell viabilities of both cell lines cells were not affected after treatment with different concentrations of both doped CNO derivatives. On the other hand, the analysis of BN-CNOs and oxidized BN-CNO interactions with zebrafish embryos did not report any kind of perturbations, in agreement with the in vitro results. Our results show that both doped CNO derivatives possess a high biocompatibility and biosafety in cells and more complex systems.
- Subjects
BIOLOGICAL systems; BIOCOMPATIBILITY; NITROGEN; BORON; CYTOCOMPATIBILITY; CELL lines
- Publication
Nanomaterials (2079-4991), 2021, Vol 11, Issue 11, p3017
- ISSN
2079-4991
- Publication type
Article
- DOI
10.3390/nano11113017