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- Title
The molecular era of the mitochondrial calcium uniporter.
- Authors
Kamer, Kimberli J.; Mootha, Vamsi K.
- Abstract
The mitochondrial calcium uniporter is an evolutionarily conserved calcium channel, and its biophysical properties and relevance to cell death, bioenergetics and signalling have been investigated for decades. However, the genes encoding this channel have only recently been discovered, opening up a new 'molecular era' in the study of its biology. We now know that the uniporter is not a single protein but rather a macromolecular complex consisting of pore-forming and regulatory subunits. We review recent studies that harnessed the power of molecular biology and genetics to characterize the mechanism of action of the uniporter, its evolution and its contribution to physiology and human disease.
- Subjects
BIOAVAILABILITY of calcium; MOLECULAR biology; MITOCHONDRIAL proteins; CALCIUM-binding proteins; MAMMALIAN cell cycle
- Publication
Nature Reviews Molecular Cell Biology, 2015, Vol 16, Issue 9, p545
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm4039