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- Title
How the ubiquitin-proteasome system controls transcription.
- Authors
Muratani, Masafumi; Tansey, William P.
- Abstract
Gene transcription and ubiquitin-mediated proteolysis are two processes that have seemingly nothing in common: transcription is the first step in the life of any protein and proteolysis the last. Despite the disparate nature of these processes, a growing body of evidence indicates that ubiquitin and the proteasome are intimately involved in gene control. Here, we discuss the deep mechanistic connections between transcription and the ubiquitin-proteasome system, and highlight how the intersection of these processes tightly controls expression of the genetic information.
- Subjects
UBIQUITIN; GENETIC transcription; PROTEOLYTIC enzymes
- Publication
Nature Reviews Molecular Cell Biology, 2003, Vol 4, Issue 3, p192
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm1049