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- Title
Factor V Leiden and thrombosis in patients with systemic lupus erythematosus: a meta-analysis.
- Authors
Kaiser, R.; Barton, J. L.; Chang, M.; Catanese, J. J.; Li, Y.; Begovich, A. B.; Criswell, L. A.
- Abstract
The aim of this study was to perform a meta-analysis of the association between the factor V Leiden polymorphism (FVL) and thrombosis among patients with systemic lupus erythematosus (SLE) and/or antiphospholipid antibody (aPL) positivity. Included studies recruited patients based on SLE or aPL-positive status, confirmed subjects’ SLE diagnosis as defined by the American College of Rheumatology, and documented thrombotic events. Excluded studies were non-English or considered only arterial thrombosis. Individual patient data, available from 5 studies, together with unpublished data from 1210 European-American SLE patients from the UCSF Lupus Genetics Collection genotyped for FVL, were further analyzed. Seventeen studies (n=2090 subjects) were included in the initial meta-analysis. Unadjusted odds ratios (OR) were calculated to assess association of FVL with thrombosis. The OR for association of thrombosis with FVL was 2.88 (95% confidence interval (CI) 1.98–4.20). In the secondary analysis with our individual patient dataset (n=1447 European-derived individuals), SLE subjects with the FVL polymorphism still had more than two times the odds of thrombosis compared to subjects without this polymorphism, even when adjusting for covariates such as gender, age and aPL status. SLE and/or aPL-positive patients with the FVL variant have more than two times the odds of thrombosis compared to those without this polymorphism.Genes and Immunity (2009) 10, 495–502; doi:10.1038/gene.2009.32; published online 7 May 2009
- Subjects
THROMBOSIS; HEMOPHILIA; SYSTEMIC lupus erythematosus; AUTOIMMUNE diseases; CONNECTIVE tissue diseases
- Publication
Genes & Immunity, 2009, Vol 10, Issue 5, p495
- ISSN
1466-4879
- Publication type
Article
- DOI
10.1038/gene.2009.32