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- Title
Successful treatment of experimental glomerulonephritis with IdeS and EndoS, IgG-degrading streptococcal enzymes.
- Authors
Rui Yang; Otten, Marielle A.; Hellmark, Thomas; Collin, Mattias; Björck, Lars; Ming-Hui Zhao; Daha, Mohamed R.; Segelmark, Mårten
- Abstract
Background. Anti-glomerular basement membrane (anti-GBM) disease often results in end-stage renal failure despite therapy with plasma exchange and immunosuppressive drugs. The newly discovered streptococcal enzymes IgG-degrading enzyme of S.pyogenes (IdeS) and endoglycosidase S (EndoS) act with remarkable specificity on circulating IgG. In this study, we investigate their ability in vivo to prevent damage mediated by kidney-bound antibodies in a mouse model of anti-GBM disease.
- Subjects
TREATMENT of glomerulonephritis; IMMUNOGLOBULIN G; ENDOGLYCOSIDASES; STREPTOCOCCUS pyogenes; IMMUNOSUPPRESSIVE agents
- Publication
Nephrology Dialysis Transplantation, 2010, Vol 25, Issue 8, p2479
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfq115