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- Title
Evaluation of penile erectile function changes by assessing the nitrate oxidase expression in rat corpus cavernosum with neck bladder obstruction and given alpha blocker.
- Authors
MARTAMBA, HUTASOIT CHARLES; SINRANG, ANDI WARDIHAN; HATTA, MOCHAMMAD; HULDANI; FAUZIAH; SUKMANA, BAYU INDRA; ACHMAD, HARUN
- Abstract
We conducted a review of evaluation erection function by assessing the expression level of nitrate oxidase in rats with neck bladder obstruction and got alpha blocker treatment. Abnormal condition of erectile dysfunction marked byitheiinability toihaveianierectioniorimaintainiiian erectioniduringiintercourse. Many factors can cause this condition. One of them is due to the low synthesis of nitric oxide. Because nitric oxide is the main mediator during erection process. Thus, nitric oxide values and erectile function are considered to have a direct relationship. While alpha blockers or alpha adrenoceptor antagonistsiplayiiiiaiiirole niiithe contraction of smooth muscle from several urinary tract organs, such as the prostate and bladder. In the case of urinary tract obstruction, alpha blockers are used as treatment. The presence of a blockade inithese receptorsiwili causeirelaxationiofithe bladderineckismoothimusclesiiiand smooth the urine flow. The uses of alpha blockers can improve erectile function. However, not all study results showes the significant differences in nitric oxide expression between before and after alpha blocker use. This may be influenced by many factors, including the type and dose of alpha blockers used.
- Subjects
BLADDER obstruction; SMOOTH muscle contraction; URINARY organs; NITRIC oxide; PENIS; NITRATES; NECK
- Publication
International Journal of Pharmaceutical Research (09752366), 2020, p920
- ISSN
0975-2366
- Publication type
Article
- DOI
10.31838/ijpr/2020.SP1.140