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- Title
Serum adropin level in wet-type age-related macular degeneration.
- Authors
Saeedi-Maleki, Zahra; Javadzadeh, Alireza; Brumandpur, Fariborz; Ghorbanihaghjo, Amir; Khanzadeh, Shokoufeh; Mousavi, Farideh
- Abstract
Purpose: Our objective was to compare the serum Adropin levels between patients with wet-type Age-Related Macular Degeneration (AMD) and otherwise healthy individuals. Method: The study included 45 patients with wet-type AMD and 45 individuals without age-related macular degeneration. Patients with co-morbidities such as diabetes, hypertension, autoimmune diseases, and a previous history of visual impairment; were excluded. FBS, Hemoglobin A1C (HbA1C), lipid profile, and serum Adropin level were checked. Results: The mean serum Adropin level of patients with wet-type AMD was significantly lower than the control group (P-value < 0.001). Also, the mean High-sensitivity C-reactive protein (hsCRP) level and High Density Lipoprotein (HDL) were significantly higher in wet-type AMD patients (P-value = 0.031 and < 0.001 respectively). Conclusions: In our study, wet-type AMD was associated with a lower level of serum Adropin. Because of Adropin involvement in glucose metabolism and age-related changes, it may have a role in the pathogenesis of AMD, but it requires more investigations at the molecular level to elucidate its function.
- Subjects
MACULAR degeneration; HIGH density lipoproteins; VISION disorders; C-reactive protein; GLUCOSE metabolism
- Publication
International Journal of Retina & Vitreous, 2024, Vol 10, Issue 1, p1
- ISSN
2056-9920
- Publication type
Article
- DOI
10.1186/s40942-024-00543-7