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- Title
Acute phase response detection and quantitation at the point of care in older adults with acute bacterial infections.
- Authors
Rogowski, Ori; Shapira, Itzhak; Berliner, Shlomo; Serov, Jack; Halpern, Pinhas; Zeltser, David; Rudensky, Bernard; Dwolatzky, Tzvi; Morley, John E.
- Abstract
<bold>Background: </bold>We investigated the reliability of a slide test in determining the presence of acute bacterial infections in a group of older adults to determine the usefulness of this test at the point of care.<bold>Methods: </bold>The study group included older adults with an acute bacterial infection and matched controls. We examined the white blood cell count (WBCC), the erythrocyte sedimentation, fibrinogen concentration, and high sensitivity C-reactive protein (hs-CRP), in addition to the slide test that reveals the number of leukocytes and degree of erythrocyte aggregation.<bold>Results: </bold>There were 144 patients and 144 controls at a respective mean +/- standard deviation age of 71.3 +/- 20.7 and 70.6 +/- 20.2 years. A highly significant difference was noted between patients and controls in all laboratory markers, both conventional and those obtained by the slide test. By using hs-CRP, we correctly predicted the individual group as control or bacterial infection. When analyzed by means of a receiver-operated characteristic (ROC) curve, hs-CRP was again most reliable, with the slide leukocyte test being superior to the WBCC.<bold>Conclusion: </bold>The slide leukocyte count provided a similar diagnostic yield to that of the WBCC. The availability of this slide test at the point of care will provide the clinician with a useful biomarker when faced with clinical decisions in the care of older adults.
- Subjects
BACTERIAL diseases; MEDICAL bacteriology; PATHOGENIC bacteria; DISEASES in older people; GERIATRICS; ACUTE phase reaction; BLOOD cells
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2005, Vol 60, Issue 10, p1324
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/60.10.1324