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- Title
Effects of Physical Exercise on Indicators of Inflammation Risk of the Gaster in a Male Wistar Rat Aging Model Created with D-galactose Induction.
- Authors
Murwaningsih, Dian; Meliala, Andreanyta; Sofro, Zaenal M.
- Abstract
Background: Physical exercise is a non-pharmacological treatment for various diseases. Aging is associated with deteriorating physiological function, and elderly individuals generally have inflammation or infection in the digestive tract. This study aimed to examine the effects of mild and moderate physical exercise intensities on the indicators of inflammation risk of the gaster in a male Wistar rat aging model created with D-galactose induction. Methods: This experimental research study had a post-test-only group design. The study included 3-month-old male Wistar rats weighing 200-300 g. The total of 24 rats were equally divided into four groups (saline,+light-intensity physical exercise, and Dgalactose+ moderate-intensity physical exercise)D-galactose, D-galactose. D-galactose was continuously administered at 300 mg/mL/kg body weight. The study period was four weeks. The number of fibrocytes, mucosal thickness, and the number and size of mucosal glands were analyzed. Results: D-galactose induction triggered aging. Physical exercise had an effect on weight gain and decreased the number of fibrocytes. However, there were no effects on mucosal thickness and the number and size of mucosal glands. Conclusions: Physical exercise of mild/moderate intensity had an effect on the number of fibrocytes but did not have impact on the mucosal thickness or the number and size of mucosal glands.
- Subjects
EXERCISE; GALACTOSE; ANIMAL models of inflammation; LABORATORY rats; BODY weight
- Publication
Makara Journal of Health Research, 2018, Vol 22, Issue 3, p147
- ISSN
2356-3664
- Publication type
Article
- DOI
10.7454/msk.v22i3.10151