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- Title
LRP-associated protein gene ( LRPAP1) and susceptibility to degenerative dementia.
- Authors
Pandey, P.; Pradhan, S.; Mittal, B.
- Abstract
Difference in genetic makeup of lipid metabolizing proteins may increase susceptibility to dementia. The aim of this study was to investigate variations in two lipid metabolizing genes, low-density lipoprotein receptor-related protein-associated protein gene ( LRPAP) and apolipoprotein E ( APOE), in vascular and degenerative dementias. This hospital-based association study included 147 patients with dementia and 163 age-matched controls. Genotyping for LRPAP1 intron 5 insertion/deletion and APOE HhaI polymorphism was carried out by polymerase chain reaction (PCR)/PCR–restriction fragment length polymorphism method. The frequency of DD genotype and *D allele of LRPAP gene was high in degenerative dementias compared with controls (76.6% vs. 44.8% and 86.4% vs. 69.3%, respectively) suggesting increased susceptibility [ P < 0.0001, odds ratio (OR) = 3.76 for DD genotype and P < 0.0001, OR = 2.80 for D allele]. Vascular dementia patients showed statistically insignificant but increasing trend for allele I (40.0% vs. 30.7%). We also observed significant association of APOEℇ4 allele with degenerative dementias ( P < 0.0001, OR = 5.35). Our study suggests that LRPAP1-D and APOE E4 alleles significantly increase the susceptibility to degenerative dementias.
- Subjects
LIPID metabolism; DEMENTIA risk factors; LOW density lipoproteins; VASCULAR dementia; GENETIC polymorphism research
- Publication
Genes, Brain & Behavior, 2008, Vol 7, Issue 8, p943
- ISSN
1601-1848
- Publication type
Article
- DOI
10.1111/j.1601-183X.2008.00436.x