We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis of New Oxopyrimidine and Cyanopyridine Derivatives Containing the Pyrimidine Benzothiazole Moiety with the Evaluating their Colon Anticancer Bioactivity.
- Authors
Abdul Maged, Abdul Gabar; AL-Lami, Naeemah
- Abstract
In this contribution, new derivatives of bicyclic fused rings with bridgehead nitrogen of 3-substituted imidazo/pyrimidine derivatives A1-A3 were synthesized by reacting 2-aminobenzothiazol, acetyl acetone, and different substituted aldehydes in a one-pot reaction. These compounds A1-A3 were then condensed with 4- bromobenzaldehyde and 4-(N,N-dimethylamino)benzaldehyde to form new chalcone derivatives A4-A9. Ring closure of these compounds A4-A9 with urea and malononitrile afforded new oxopyrimidine derivatives A10-A15 and cyanopyridine derivatives A16-A21, respectively. These compounds were characterized by FT-IR, 1H NMR, and 13C NMR spectroscopy. The second part of this work included some of the important applications conducted for these compounds to evaluate their biological activities against colon cancer, which showed excellent results against this disease.
- Subjects
PYRIMIDINE derivatives; CYCLIC compounds; BENZOTHIAZOLE; UREA compounds; COLON (Anatomy); PYRIMIDINES
- Publication
Iraqi Journal of Science, 2023, Vol 64, Issue 8, p3725
- ISSN
0067-2904
- Publication type
Article
- DOI
10.24996/ijs.2023.64.8.1