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- Title
New Monocyclic Terpenoid Lactones from a Brown Algae Sargassum macrocarpum as Monoamine Oxidase Inhibitors.
- Authors
Kwon, Jaeyoung; Lee, Kyerim; Hwang, Hoseong; Kim, Seong-Hwan; Park, Se Eun; Durai, Prasannavenkatesh; Park, Keunwan; Kim, Hyung-Seop; Jang, Dae Sik; Choi, Jae Sue; Kwon, Hak Cheol
- Abstract
Algae are unique natural products that can produce various types of biologically active compounds. The 70% ethanol extract of brown algae Sargassum macrocarpum collected from the East Sea of Korea inhibited human monoamine oxidases A and B enzymes (hMAO-A and hMAO-B) at a 50 μg/mL concentration. The bioassay-guided isolation was performed through solid-phase extraction and the Sepbox system followed by serial high-performance liquid chromatography on the reverse phase condition, resulting in the identification of two new monocyclic terpenoid lactones, sargassumins A and B (1 and 2). The planar structures of the compounds were determined by a combination of spectroscopic data. The absolute configurations were determined by the interpretation of circular dichroism data. Compound 1 exhibited mild hMAO-A inhibition (42.18 ± 2.68% at 200 μM) and docked computationally into the active site of hMAO-A (−8.48 kcal/mol). Although compound 2 could not be tested due to insufficient quantity, it docked better into hMAO-A (−9.72 kcal/mol). Therefore, the above results suggest that this type of monocyclic terpenoid lactone could be one of the potential lead compounds for the treatment of psychiatric or neurological diseases.
- Subjects
SOUTH Korea; MONOAMINE oxidase inhibitors; SARGASSUM; BIOACTIVE compounds; REVERSE phase liquid chromatography; BROWN algae; HIGH performance liquid chromatography
- Publication
Plants (2223-7747), 2022, Vol 11, Issue 15, p1998
- ISSN
2223-7747
- Publication type
Article
- DOI
10.3390/plants11151998