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- Title
Deferasirox associated with liver failure and death in a sickle cell anemia patient homozygous for the −1774delG polymorphism in the Abcc2 gene.
- Authors
Braga, Caroline C. B.; Benites, Bruno Deltreggia; Albuquerque, Dulcineia M.; Alvarez, Marisa C.; Seva‐Pereira, Tiago; Duarte, Bruno K. L.; Costa, Fernando F.; Gilli, Simone C. O.; Saad, Sara T. O.
- Abstract
Key Clinical Message This manuscript describes the case of a patient with sickle cell anemia who died of fulminant hepatitis after therapy with the iron chelator Deferasirox. The patient was homozygous for the −1774delG polymorphism in the Abcc2 gene, which raises the concern about the use of hepatotoxic drugs in this specific context.
- Subjects
SICKLE cell anemia; HEPATITIS; THERAPEUTIC use of iron chelates; LIVER failure; HEPATOTOXICOLOGY; PATIENTS; THERAPEUTICS
- Publication
Clinical Case Reports, 2017, Vol 5, Issue 8, p1218
- ISSN
2050-0904
- Publication type
Article
- DOI
10.1002/ccr3.1040