We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Deciphering and Targeting Oncogenic Mutations and Pathways in Breast Cancer.
- Authors
Santarpia, Libero; Bottai, Giulia; Kelly, Catherine M.; Győrffy, Balázs; Székely, Borbala; Pusztai, Lajos
- Abstract
Advances in DNA and RNA sequencing revealed substantially greater genomic complexity in breast cancer than simple models of a few driver mutations would suggest. Only very few, recurrent mutations or copy-number variations in cancer-causing genes have been identified. The two most common alterations in breast cancer are TP53 (affecting the majority of triple-negative breast cancers) and PIK3CA (affecting almost half of estrogen receptor-positive cancers) mutations, followed by a long tail of individually rare mutations affecting,1%-20% of cases. Each cancer harbors from a few dozen to a few hundred potentially high-functional impact somatic variants, along with a much larger number of potentially high-functional impactgermline variants. It is likely that it is the combined effect of all genomic variations that drives the clinical behavior of a given cancer. Furthermore, entirely new classes of oncogenic events are being discovered in the noncoding areas of the genome and in noncoding RNA species driven by errors in RNA editing. In light of this complexity, it is not unexpected that, with the exception of HER2 amplification, no robust molecular predictors of benefit from targeted therapies have been identified. In this review, we summarize the current genomic portrait of breast cancer, focusing on genetic aberrations that are actively being targeted with investigational drugs.
- Subjects
ANTINEOPLASTIC agents; BREAST tumors; DISEASE susceptibility; GENES; MEDICAL information storage &; retrieval systems; MEDLINE; METASTASIS; GENETIC mutation; ONLINE information services; SYSTEMATIC reviews; GENOMICS; RANDOMIZED controlled trials; GENETICS
- Publication
Oncologist, 2016, Vol 21, Issue 9, p1063
- ISSN
1083-7159
- Publication type
Article
- DOI
10.1634/theoncologist.2015-0369