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- Title
Hypoxia-inducible factor-2α is involved in enhanced apoptosis in the placenta from pregnancies with fetal growth restriction.
- Authors
Dai, Shu-Yan; Kanenishi, Kenji; Ueno, Masaki; Sakamoto, Haruhiko; Hata, Toshiyuki
- Abstract
The aim of the present study is to investigate whether hypoxia-inducible factors (HIF-1α, HIF-2α, HIF-1β) are involved in enhanced apoptosis in the human placenta from pregnancies with fetal growth restriction (FGR). Placental samples were obtained from women with normal term pregnancy (n = 18) or from pregnancy with FGR (n = 12). Placenta apoptosis was assessed by the terminal deoxynucleotidyl transferase deoxy-UTP-nick end labeling (TUNEL) staining. The expressions of HIF-1α, HIF-2α, and HIF-1β were examined by immunohistochemical analysis. Enhanced apoptosis was observed in the placenta from pregnancies with FGR compared with normal term placenta. The apoptosis index in FGR group (1.45 ± 1.26%) was significantly higher than that in the normal control group (0.18 ± 0.16%;P < 0.01). There were no significant differences in the intensity of the staining for HIF-1α and HIF-1β expressions between two groups, while HIF-2α was overexpressed in the placenta from pregnancies with FGR group (P < 0.05). The upregulation of HIF-2α protein expression in the placenta from pregnancies with FGR may, at least in part, be involved in the increased placental apoptosis.
- Subjects
APOPTOSIS; CELL death; PLACENTA; HYPOXEMIA; PREGNANCY; FETAL development; STAINS &; staining (Microscopy); OBSTETRICS
- Publication
Pathology International, 2004, Vol 54, Issue 11, p843
- ISSN
1320-5463
- Publication type
Article
- DOI
10.1111/j.1440-1827.2004.01750.x