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- Title
Chronic hand eczema: A prospective analysis of the Swiss CARPE registry focusing on factors associated with clinical and quality of life improvement.
- Authors
Borradori, Luca; Simon, Dagmar; Cazzaniga, Simone; Sonntag, Anne‐Katharina; Piletta, Pierre; Huber, Caroline; Diepgen, Thomas L.; Apfelbacher, Christian; Naldi, Luigi; Gräni, Nora; Ballmer‐Weber, Barbara K.; Spring, Philippe; Bircher, Andreas; Anliker, Mark
- Abstract
Background: Hand eczema (HE) is common and may follow a chronic disease course. So far, prospective studies investigating the risk factors for disease progression as a prerequisite for targeted prevention are scarce. Objective: To evaluate the overall association of HE‐associated factors with clinical and quality of life (QoL) improvement during a follow‐up of 2 years. Methods: Data of the prospective patient cohort (N = 199) followed by the Swiss chronic HE (CHE) registry on long‐term patient management (CARPE‐CH) were analysed by means of both classic regression and semantic map analyses. Results: Both severity of HE and QoL significantly improved over the period of 2 years (P < .001). However, 20% of patients had moderate to severe HE after 2 years of follow‐up. As factors associated with an unfavourable CHE clinical course and QoL, environmental exposures, male sex, occupational skin disease, job loss or change at baseline, allergic contact dermatitis, a chronic disease course, palmar localization and widespread eczema were identified. Conclusions: Analysis of prospective data from CARPE‐CH shows a complex pattern of associations among variables as shown by semantic map and classic statistical analyses. Factors related to occupational exposure had the highest impact on CHE.
- Subjects
ECZEMA; QUALITY of life; CHRONIC diseases; DISEASE progression; HEALTH of patients
- Publication
Contact Dermatitis (01051873), 2018, Vol 79, Issue 3, p136
- ISSN
0105-1873
- Publication type
Article
- DOI
10.1111/cod.13041