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- Title
Effects of Sample-dissolving Solvent and Sample Ionic Strength in Routine CE Operation.
- Authors
Altria, Kevin
- Abstract
The ionic strength of a sample and the solvent used to dissolve it play a pivotal role in routine capillary electrophoresis (CE). The effects of these parameters can be very pronounced, ranging from improved separation and sensitivity to loss of resolution, shifting migration times, and even to equipment breakdown. CE practitioners should pay special attention to the sample-dissolving solvent and the ionic strength of the sample during method development, validation and routine operation.
- Subjects
IONIC solutions; CAPILLARY electrophoresis; ORGANIC solvents; ELECTROCHEMISTRY; PHASE partition; SEPARATION (Technology)
- Publication
LC-GC Europe, 2008, Vol 21, Issue 4, p208
- ISSN
1471-6577
- Publication type
Article