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- Title
Molecular analysis of viral factors responsible for the acquisition of pathogenicity by a live attenuated classical swine fever vaccine strain by serial passages in pigs.
- Authors
Tamura, Tomokazu
- Abstract
The article focuses on a study regarding the amino acids responsible for the acquisition of pathogenicity of the live attenuated classical swine fever vaccine strain, GPE. The study involved mutant viruses that were generated by reverse genetics and site-directed mutagenesis of the GPE backbone. The result showed that the three amino acid substitutions, T830A on E2, and V2475a and A2563V on NS4B, affect virus entry and replication, causing the acquisition of pathogenicity.
- Subjects
AMINO acids; SWINE diseases; VIRUSES; REVERSE genetics; MUTAGENESIS
- Publication
Japanese Journal of Veterinary Research, 2012, Vol 60, Issue 2/3, p157
- ISSN
0047-1917
- Publication type
Article