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- Title
Anabolic effect of Butea superba Roxb. on improving skeletal muscle atrophy and strength via androgen receptors and increasing parvalbumin levels in orchidectomized rats.
- Authors
Binalee, Fadeela; Udomuksorn, Wandee; Kumarnsit, Ekkasit; Vongvatcharanon, Uraporn; Vongvatcharanon, Surapong
- Abstract
Butea superba Roxb. (BS) has been used in Thai traditional medicine for the promotion of male sexual vigor. BS may have androgenic or anabolic activity in male animals. This study investigated the effect of BS on toxicity and androgenic and anabolic activities including alteration of androgen receptor immunoreactivity (AR-ir) and parvalbumin (PV) levels in an extensor digitorum longus (EDL) and gastrocnemius in orchidectomized rats. Adult male Wistar rats were divided into 6 groups: (1) sham-operated (SHAM), (2) orchidectomized and double distilled water treated (BS-0), (3) orchidectomized and 6 mg/kg of testosterone propionate treated (TP), orchidectomized and BS treated for 12 weeks at various doses: (4) 5 mg/kg (BS-5), (5) 50 mg/kg (BS-50), and (6) 500 mg/kg (BS-500). All the BS groups led to a significant decrease in testosterone level and the reproductive organ weight compared to those of the SHAM (p < 0.05). In addition, the treatment in all doses of BS may have no toxicity. Interestingly, the treatment with any dose of BS significantly increased strength, endurance, muscle mass, PV levels (p < 0.05), and AR-ir of both EDL and gastrocnemius. Our data also demonstrated that the BS had no androgenic effects but showed anabolic effects by increasing mass, strength, and endurance of skeletal muscles. An increase of PV levels induced by BS may be an important mechanism for improving muscle strength and endurance of skeletal muscles in orchidectomized rats. Therefore, the anabolic effects of BS may be a piece of useful information for an alternative treatment of sarcopenia in andropause.
- Subjects
MUSCLE strength; MUSCULAR atrophy; SARCOPENIA; MUSCLE mass; GENITALIA; SKELETAL muscle; RATS; ANDROGEN receptors
- Publication
ScienceAsia, 2022, Vol 48, Issue 6, p718
- ISSN
1513-1874
- Publication type
Article
- DOI
10.2306/scienceasia1513-1874.2022.102