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- Title
The Role of Fine Needle Aspiration Cytology in the Diagnosis of Gallbladder Cancer: A Systematic Review.
- Authors
Koimtzis, Georgios D.; Chalklin, Christopher G.; Carrington-Windo, Eliot; Ramsden, Mark; Stefanopoulos, Leandros; Kosmidis, Christoforos S.
- Abstract
Gallbladder cancer is the most common malignancy of the biliary tract. When diagnosed in an advanced stage it has a very poor prognosis. Therefore, early diagnosis and thorough assessment of a suspicious gallbladder polyp is essential to improve survival rate. The aim of this systematic review is to assess the role of fine needle aspiration cytology (FNAC) in the management of gallbladder cancer. For that purpose, a systematic review was carried out in the MEDLINE, EMBASE, Cochrane, Scopus and Google Scholar databases between 1 July 2004 and 22 April 2021. Six studies with 283 patients in total were included. Pooled sensitivity and specificity of FNAC were 0.85 and 0.94, respectively, while the area under the calculated summary receiver operating characteristic (SROC curve (AUC) was 0.98. No complications were reported. Based on the high diagnostic performance of FNAC in the assessment of gallbladder masses, we suggest that every suspicious mass should be evaluated further with FNAC to facilitate the most appropriate management.
- Subjects
GALLBLADDER cancer; NEEDLE biopsy; CANCER diagnosis; GOOGLE Scholar (Web resource); CYTOLOGY; SURVIVAL rate; BILIARY tract
- Publication
Diagnostics (2075-4418), 2021, Vol 11, Issue 8, p1427
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics11081427