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- Title
A quantitative analysis of body mass index and colorectal cancer: findings from 56 observational studies.
- Authors
Ning, Y.; Wang, L.; Giovannucci, E. L.
- Abstract
To perform a systematic review of studies reporting on the association between body mass index (BMI) and the risk of colorectal cancer, we conducted a meta-analysis and meta-regression analysis. The identified 56 studies were conducted among 7 213 335 individuals including 93 812 cases. Compared with BMI < 23.0 kg m−2, BMI of 23.0–24.9, 25.0–27.4, 27.5–29.9 and ≥30.0 kg m−2 were associated with 14%, 19%, 24% and 41% increased risks, respectively. Asians and premenopausal women had sharply increased risk from BMI < 23 kg m−2 to general ‘normal’ range (23–25 kg m−2). Each 5 kg m−2 increment was associated with 18% increased risk. Meta-regression analysis indicated that the association was stronger for colon than rectal cancer ( P < 0.001), for men than women ( P < 0.001), for self-reported BMI than directly measured BMI ( P < 0.001), and for studies adjusting for physical activity than not adjusting ( P < 0.001). The variation of the reported risk estimates for the association can be partly explained by cancer site, sex, women menopausal status, BMI assessment and adjustment of confounding variables.
- Subjects
BODY mass index; OBESITY; COLON cancer; META-analysis; SYSTEMATIC reviews
- Publication
Obesity Reviews, 2010, Vol 11, Issue 1, p19
- ISSN
1467-7881
- Publication type
Article
- DOI
10.1111/j.1467-789X.2009.00613.x