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- Title
A randomized controlled proof‐of‐concept trial of digoxin and furosemide in adults with cutaneous warts.
- Authors
Rijsbergen, M.; Niemeyer‐van der Kolk, T.; Hogendoorn, G.; Kouwenhoven, S.; Lemoine, C.; Klaassen, E.S.; de Koning, M.; Beck, S.; Bouwes Bavinck, J.N.; Feiss, G.; Burggraaf, J.; Rissmann, R.
- Abstract
Summary: Background: Topical ionic contraviral therapy (ICVT) with digoxin and furosemide inhibits the potassium influx on which DNA viruses rely for replication. Therefore, ICVT was hypothesized to be a potential novel treatment for cutaneous warts. Objectives: To assess the clinical efficacy, safety and tolerability of ICVT in adults with cutaneous warts. The secondary objective was to gain insight into the underlying working mechanism of ICVT. Methods: Treatment with ICVT was assessed for efficacy, safety and tolerability in a single‐ centre, randomized, double‐blind, placebo‐controlled phase IIA trial. Eighty adult patients with at least two cutaneous warts (plantar or common) were randomized to one of four treatments: digoxin + furosemide (0·125%), digoxin (0·125%), furosemide (0·125%) or placebo. The gel was administered once daily for 42 consecutive days. Predefined statistical analysis was performed with a mixed‐model ancova. The trial was registered at ClinicalTrials.gov with number NCT02333643. Results: Wart size and human papillomavirus (HPV) load reduction was achieved in all active treatment groups. A statistically significant reduction in wart diameter of all treated warts was shown in the digoxin + furosemide treatment group vs. placebo (−3·0 mm, 95% confidence interval −4·9 to −1·1, P = 0·002). There was a statistically significant reduction in the HPV load of all treated warts in the digoxin + furosemide group vs. placebo (−94%, 95% confidence interval −100 to −19, P = 0·03). With wart size reduction, histologically and immunohistochemically defined viral characteristics disappeared from partial and total responding warts. Conclusions: This study demonstrates the proof of concept for the efficacy of topical ICVT in adults with cutaneous warts. What's already known about this topic? Cutaneous warts are caused by the human papillomavirus (HPV).Ionic contraviral therapy (ICVT) might be a potential treatment for cutaneous warts.A previous phase I/II open‐label study demonstrated the safety and efficacy of ICVT. What does this study add? Proof of concept for the efficacy of topical ICVT in adults with cutaneous warts.Topical ICVT demonstrates a favourable safety profile, with the effects most pronounced when it is combined in a formulation for common warts.Wart size reduction was related to HPV load reduction measured by quantitative polymerase chain reaction (qPCR) in swabs.qPCR is a valuable disease biomarker for drug development in cutaneous warts. Plain language summary available online Respond to this article
- Subjects
WARTS; RANDOMIZED controlled trials; IONTOPHORESIS; FUROSEMIDE; POLYMERASE chain reaction; DNA viruses
- Publication
British Journal of Dermatology, 2019, Vol 180, Issue 5, p1058
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/bjd.17583