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- Title
Exosomes as drug delivery system in gastrointestinal cancer.
- Authors
Fangyuan Xie; Yueying Huang; Yangyang Zhan; Leilei Bao
- Abstract
Gastrointestinal cancer is one of the most common malignancies with relatively high morbidity and mortality. Exosomes are nanosized extracellular vesicles derived from most cells and widely distributed in body fluids. They are natural endogenous nanocarriers with low immunogenicity, high biocompatibility, and natural targeting, and can transport lipids, proteins, DNA, and RNA. Exosomes contain DNA, RNA, proteins, lipids, and other bioactive components, which can play a role in information transmission and regulation of cellular physiological and pathological processes during the progression of gastrointestinal cancer. In this paper, the role of exosomes in gastrointestinal cancers is briefly reviewed, with emphasis on the application of exosomes as drug delivery systems for gastrointestinal cancers. Finally, the challenges faced by exosome-based drug delivery systems are discussed.
- Subjects
GASTROINTESTINAL cancer; DRUG delivery systems; EXOSOMES; EXTRACELLULAR vesicles; GENE targeting
- Publication
Frontiers in Oncology, 2023, Vol 13, p01
- ISSN
2234-943X
- Publication type
Article
- DOI
10.3389/fonc.2022.1101823