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- Title
Synthesis, Characterization, X-Ray Crystallography, and Antileishmanial Activities of N-Linked and O-Linked Glycopyranosides.
- Authors
Rashid, Haroon ur; Khan, Sher Wali; Khan, Momin; Nadhman, Akhtar; Rehman, Noor; Tariq, Muhammad; Yousuf, Sammer
- Abstract
Novel N-linked<bold> 5a</bold>–<bold>e</bold> and O-linked glycopyranosides<bold> 7a</bold>–<bold>e</bold> were synthesized in high yield from commercially available L-tartaric acid containing two asymmetric centers and C2 axis of symmetry. The compound L-tartaric acid was completely protected and then partially hydrolyzed to get the monoester, which upon treatment with different amino and hydroxyl derivatives of glycopyranoses gave the desired amides and esters. The synthesized derivatives were purified by chromatography and characterized by spectroanalytical techniques. The structure of compound<bold> 7c</bold> in the series was supported by X-ray analysis. Leishmanicidal activities of compounds<bold> 5a</bold>–<bold>e</bold> and<bold> 7a</bold>–<bold>e</bold> were investigated which showed moderate to good activities.
- Subjects
X-ray crystallography; GLYCOPROTEINS; GLYCOLIPIDS; LEISHMANIA donovani; REGULATION of cell growth; THERAPEUTICS
- Publication
Journal of Chemistry, 2018, p1
- ISSN
2090-9063
- Publication type
Article
- DOI
10.1155/2018/9648710