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- Title
Editorial: Advances in the Immunology of Host Defense Peptide: Mechanisms and Applications of Antimicrobial Functions and Beyond.
- Authors
Phan, Thanh Kha; Bevins, Charles L.; Hulett, Mark D.
- Abstract
Undoubtedly, machine learning will help revolutionize future HDP discovery, which should not only shed light upon HDP biology in understudied organisms (such as plant HDPs as argued by Petre), but also expand the HDP arsenal for therapeutic exploitation. Keywords: immunomodulation; antimicrobial peptides; host defense peptides; antibiotic resistance; innate immunity EN immunomodulation antimicrobial peptides host defense peptides antibiotic resistance innate immunity N.PAG N.PAG 4 03/03/21 20210225 NES 210225 Introduction The term "antimicrobial peptides" (AMPs) classically refers to naturally occurring molecules that are made by most living organisms as key components of innate immunity that help shape the composition of colonizing micrbiota and provide a first line of defense against invading microbial pathogens. Forsaking the classical term "antimicrobial peptides" and embracing "host defense peptides" can not only properly acknowledge the multi-functionality and complexity of HDPs, but may also imprint the currently underexplored activity landscapes and enshrouded therapeutic potential of HDPs.
- Subjects
PEPTIDE antibiotics; IMMUNOLOGY; ANTIMICROBIAL peptides; PATHOLOGY; INFLAMMATORY bowel diseases; MULTIDRUG resistance in bacteria
- Publication
Frontiers in Immunology, 2021, Vol 11, pN.PAG
- ISSN
1664-3224
- Publication type
Editorial
- DOI
10.3389/fimmu.2021.637641