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- Title
Perspectives on fetal derived CD5<sup>+</sup> B1 B cells.
- Authors
Hardy, Richard R.; Hayakawa, Kyoko
- Abstract
CD5+ B-cell origins and their predisposition to lymphoma are long-standing issues. Transfer of fetal and adult liver BM Pro-B cells generates B cells with distinct phenotypes: fetal cells generate IgMhighIgDlowCD5+, whereas adult cells IgMlowIgDhighCD5-. This suggests a developmental switch in B lymphopoiesis, similar to the switch in erythropoiesis. Comparison of mRNA and miRNA expression in fetal and adult Pro-B cells revealed differential expression of Lin28b mRNA and Let-7 miRNA, providing evidence that this regulatory axis functions in the switch. Recent work has shown that Arid3a is a key transcription factor mediating fetal-type B-cell development. Lin28b-promoted fetal development generates CD5+ B cells as a consequence of positively selected self-reactivity. CD5+ B cells play important roles in clearance of apoptotic cells and in protective immune responses, but also pose a risk of progression to leukemia/lymphoma. Differential Lin28b expression in fetal and adult human B-cell precursors showed that human B-cell development may resemble mouse, with self-reactive 'innate-like' B cells generated early in life. It remains to be determined whether such human B cells have a higher propensity to leukemic progression. This review describes our recent research with CD5+ B cells and presents our perspective on their role in disease.
- Publication
European Journal of Immunology, 2015, Vol 45, Issue 11, p2978
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.201445146