We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Application of an analytical framework for multivariate mediation analysis of environmental data.
- Authors
Aung, Max T.; Song, Yanyi; Ferguson, Kelly K.; Cantonwine, David E.; Zeng, Lixia; McElrath, Thomas F.; Pennathur, Subramaniam; Meeker, John D.; Mukherjee, Bhramar
- Abstract
Diverse toxicological mechanisms may mediate the impact of environmental toxicants (phthalates, phenols, polycyclic aromatic hydrocarbons, and metals) on pregnancy outcomes. In this study, we introduce an analytical framework for multivariate mediation analysis to identify mediation pathways (q = 61 mediators) in the relationship between environmental toxicants (p = 38 analytes) and gestational age at delivery. Our analytical framework includes: (1) conducting pairwise mediation for unique exposure-mediator combinations, (2) exposure dimension reduction by estimating environmental risk scores, and (3) multivariate mediator analysis using either Bayesian shrinkage mediation analysis, population value decomposition, or mediation pathway penalization. Dimension reduction demonstrates that a one-unit increase in phthalate risk score is associated with a total effect of 1.07 lower gestational age (in weeks) at delivery (95% confidence interval: 0.48–1.67) and eicosanoids from the cytochrome p450 pathway mediated 26% of this effect (95% confidence interval: 4–63%). Eicosanoid products derived from the cytochrome p450 pathway may be important mediators of phthalate toxicity. Diverse toxicological mechanisms may mediate the impact of environmental toxicants on pregnancy outcomes. In this study the authors introduce an analytical framework for multivariate mediation analysis to identify mediation pathways in the relationship between environmental toxicants and gestational age at delivery.
- Subjects
MEDIATION (Statistics); MULTIVARIATE analysis; PREGNANCY outcomes; POLYCYCLIC aromatic hydrocarbons; DATA analysis; PHTHALATE esters; CYTOCHROME P-450
- Publication
Nature Communications, 2020, Vol 11, Issue 1, pN.PAG
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-020-19335-2