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- Title
Effects of FK506 on Hippocampal CA1 Cells Following Transient Global Ischemia/Reperfusion in Wistar Rat.
- Authors
Sharifi, Zahra-Nadia; Abolhassani, Farid; Zarrindast, Mohammad Reza; Movassaghi, Shabnam; Rahimian, Nasrin; Hassanzadeh, Gholamreza
- Abstract
Transient global cerebral ischemia causes loss of pyramidal cells in CA1 region of hippocampus. In this study, we investigated the neurotrophic effect of the immunosuppressant agent FK506 in rat after global cerebral ischemia. Both common carotid arteries were occluded for 20 minutes followed by reperfusion. In experimental group 1, FK506 (6 mg/kg) was given as a single dose exactly at the time of reperfusion. In the second group, FK506 was administered at the beginning of reperfusion, followed by its administration intraperitoneally (IP) 6, 24, 48, and 72 hours after reperfusion. FK506 failed to show neurotrophic effects on CA1 region when applied as a single dose of 6mg/kg. The cell number and size of the CA1 pyramidal cells were increased, also the number of cell death decreased in this region when FK506 was administrated 48 h after reperfusion. This work supports the possible use of FK506 in treatment of ischemic brain damage.
- Subjects
ANALYSIS of variance; ANIMAL experimentation; BRAIN; CEREBRAL ischemia; HIPPOCAMPUS (Brain); IMMUNOSUPPRESSIVE agents; PROBABILITY theory; RATS; REPERFUSION injury; RESEARCH funding; EVALUATION research; DATA analysis software; INVESTIGATIONAL drugs
- Publication
Stroke Research & Treatment, 2012, p1
- ISSN
2090-8105
- Publication type
Article
- DOI
10.1155/2012/809417