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- Title
Pandemic Influenza A (H1N1) Virus Infection Increases Apoptosis and HIV-1 Replication in HIV-1 Infected Jurkat Cells.
- Authors
Xue Wang; Jiying Tan; Biswas, Santanu; Jiangqin Zhao; Devadas, Krishnakumar; Zhiping Ye; Hewlett, Indira
- Abstract
Influenza virus infection has a significant impact on public health, since it is amajor cause of morbidity and mortality. It is not well-known whether influenza virus infection affects cell death and human immunodeficiency virus (HIV)-1 replication in HIV-1-infected patients. Using a lymphoma cell line, Jurkat, we examined the in vitro effects of pandemic influenza A (H1N1) virus (pH1N1) infection on cell death and HIV-1 RNA production in infected cells. We found that pH1N1 infection increased apoptotic cell death through Fas and Bax-mediated pathways in HIV-1-infected Jurkat cells. Infection with pH1N1 virus could promote HIV-1 RNA production by activating host transcription factors including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), nuclear factor of activated T-cells (NFAT) and activator protein 1 (AP-1) through mitogen-activated protein kinases (MAPK) pathways and T-cell antigen receptor (TCR)-related pathways. The replication of HIV-1 latent infection could be reactivated by pH1N1 infection through TCR and apoptotic pathways. These data indicate that HIV-1 replication can be activated by pH1N1 virus in HIV-1-infected cells resulting in induction of cell death through apoptotic pathways.
- Subjects
INFLUENZA A virus, H1N1 subtype; H1N1 influenza; APOPTOSIS; CELL death; VIRAL replication; BACTERIOPHAGE replication
- Publication
Viruses (1999-4915), 2016, Vol 8, Issue 2, p33
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v8020033