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- Title
Brief Report: Associations Between Self-injurious Behaviors and Abdominal Pain Among Individuals with ASD-Associated Disruptive Mutations.
- Authors
Kurtz-Nelson, Evangeline C.; Tham, See Wan; Ahlers, Kaitlyn; Cho, Daniel; Wallace, Arianne S.; Eichler, Evan E.; Bernier, Raphael A.; Earl, Rachel K.
- Abstract
Self-injurious behaviors (SIB) are elevated in autism spectrum disorder (ASD) and related genetic disorders, but the genetic and biological mechanisms that contribute to SIB in ASD are poorly understood. This study examined rates and predictors of SIB in 112 individuals with disruptive mutations to ASD-risk genes. Current SIB were reported in 30% of participants and associated with poorer cognitive and adaptive skills. History of severe abdominal pain predicted higher rates of SIB and SIB severity after controlling for age and adaptive behavior; individuals with a history of severe abdominal pain were eight times more likely to exhibit SIB than those with no history. Future research is needed to examine associations between genetic risk, pain, and SIB in this population.
- Subjects
GENETICS of autism; RISK factors of self-injurious behavior; ADAPTABILITY (Personality); GENETIC mutation; GENETIC disorders; COGNITION; RISK assessment; AUTISM; ABDOMINAL pain; PEOPLE with intellectual disabilities; DISEASE complications
- Publication
Journal of Autism & Developmental Disorders, 2021, Vol 51, Issue 9, p3365
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-020-04774-z