We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
An Exploratory Study of the Association between <i>KCNB1</i> rs1051295 and Type 2 Diabetes and Its Related Traits in Chinese Han Population.
- Authors
Zhang, Yu-Xiang; Liu, Yan; Dong, Jing; Wang, You-Xin; Wang, Jing; Zhuang, Guo-Qing; Han, Shu-Jing; Guo, Qing-Qing; Luo, Yan-Xia; Zhang, Jie; Peng, Xiao-Xia; Zhang, Ling; Yan, Yu-Xiang; Yang, Xing-hua; Wang, Hong; Han, Xu; Liu, Guang-Xu; Kang, You-Hou; Liu, You-Qin; Weng, Sheng-Feng
- Abstract
Since the KCNB1 encoding Kv2.1 channel accounts for the majority of Kv currents modulating insulin secretion by pancreatic islet beta-cells, we postulated that KCNB1 is a plausible candidate gene for genetic variation contributing to the variable compensatory secretory function of beta-cells in type-2 diabetes (T2D). We conducted two studies, a case-control study and a cross-section study, to investigate the association of common single-nucleotide polymorphisms (SNPs) in KCNB1 with T2D and its linking traits. In the case-control study, we first examined the association of 20 tag SNPs of KCNB1 with T2D in a population with 226 T2D patients and non-diabetic subjects (screening study). We then identified the association in an enlarged population of 412 T2D patients and non-diabetic subjects (replication study). In the cross-sectional study, we investigated the linkage between the candidate SNP rs1051295 and T2D by comparing beta-cell function and insulin sensitivity among rs1051295 genotypes in a general population of 1051 subjects at fasting and after glucose loading (oral glucose tolerance tests, OGTT) in 84 fasting glucose impaired subjects, and several T2D-related traits. We found that among the 19 available tag SNPs, only the KCNB1 rs1051295 was associated with T2D (P = 0.027), with the rs1051295 TT genotype associated with an increased risk of T2D compared with genotypes CC (P = 0.009). At fasting, rs1051295 genotype TT was associated with a 9.8% reduction in insulin sensitivity compared to CC (P = 0.008); along with increased plasma triglycerides (TG) levels (TT/CC: P = 0.046) and increased waist/hip (W/H) ratio (TT/CC: P = 0.013; TT/TC: P = 0.002). OGTT confirmed that genotype TT exhibited reduced insulin sensitivity by 16.3% (P = 0.030) compared with genotype TC+CC in a fasting glucose impaired population. The KCNB1 rs1051295 genotype TT in the Chinese Han population is associated with decreased insulin sensitivity and increased plasma TG and W/H ratio, which together contribute to an increased risk for T2D.
- Subjects
TYPE 2 diabetes; CHINESE people; SECRETION; PANCREATIC beta cells; ISLANDS of Langerhans; SINGLE nucleotide polymorphisms; ENDOCRINOLOGY; POTASSIUM channels; DISEASES
- Publication
PLoS ONE, 2013, Vol 8, Issue 2, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0056365