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- Title
Synthesis of Chiral Aziridines from Glycals: Application in the Synthesis of a Piperidine–Azepine Fused Derivative.
- Authors
Thakur, Rima; Rawal, Girish K.; Vankar, Yashwant D.
- Abstract
Vicinal chloroamines derived from glycals have been converted into the corresponding chiral aziridines. Although the formation of a tetrahydrofuran derivative is also possible, reaction conditions were developed to give the azirdines exclusively. One of the aziridines is closely related to a compound used in the synthesis of an advanced intermediate en route to Zanamivir, an antiviral agent. Furthermore, one of the aziridines was converted into a piperidine–azepine fused derivative
- Subjects
AZIRIDINATION; GLYCALS; PIPERIDINE; AZEPINES; CHLORAMINES; TETRAHYDROFURAN derivatives
- Publication
European Journal of Organic Chemistry, 2017, Vol 2017, Issue 29, p4235
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201700624