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- Title
Propofol in neonates causes a dose-dependent profound and protracted decrease in blood pressure.
- Authors
Kort, Ellen H. M.; Twisk, Jos W. R.; t Verlaat, Ellen P. G.; Reiss, Irwin K. M.; Simons, Sinno H. P.; Weissenbruch, Mirjam M.; de Kort, Ellen H M; van T Verlaat, Ellen P G; van Weissenbruch, Mirjam M
- Abstract
<bold>Aim: </bold>To analyse the effects of different propofol starting doses as premedication for endotracheal intubation on blood pressure in neonates.<bold>Methods: </bold>Neonates who received propofol starting doses of 1.0 mg/kg (n = 30), 1.5 mg/kg (n = 23) or 2.0 mg/kg (n = 26) as part of a previously published dose-finding study were included in this analysis. Blood pressure in the 3 dosing groups was analysed in the first 60 minutes after start of propofol.<bold>Results: </bold>Blood pressure declined after the start of propofol in all 3 dosing groups and was not restored 60 minutes after the start of propofol. The decline in blood pressure was highest in the 2.0 mg/kg dosing group. Blood pressure decline was mainly dependent on the initial propofol starting dose rather than the cumulative propofol dose.<bold>Conclusion: </bold>Propofol causes a dose-dependent profound and prolonged decrease in blood pressure. The use of propofol should be carefully considered. When using propofol, starting with a low dose and titrating according to sedative effect seems the safest strategy.
- Subjects
BLOOD pressure; PROPOFOL; HYPERTENSION; NEWBORN infants; TRACHEA intubation; RESEARCH; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; INTRAVENOUS anesthetics; COMPARATIVE studies; HEART beat; PREANESTHETIC medication
- Publication
Acta Paediatrica, 2020, Vol 109, Issue 12, p2539
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1111/apa.15282