Glucocorticosteroids (GCS) have been frequently used for a number of dermatologic conditions since the early 1950s. These drugs continue to be very efficacious, yet there are serious side effects associated with their long-term use. Significant complications produced by GCS can be minimized by proper management and precautions. All health care professionals should be aware of these strategies and nursing personnel can play a vital role in helping patients adhere to the guidelines of preventing adverse events.