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- Title
The Fc Binding Regions in Protein A are not Responsible for the Polyclonal B Cell Activating Property of Protein A.
- Authors
Sjödahl, J.; Möller, G.
- Abstract
To test whether the polyclonal B cell activating property of protein A is due to its ability to bind to the Fc part of immunoglobulins, experiments were carried out with purified monomeric or dimeric Fc-binding fragments of protein A. Neither monomeric nor dimeric fragments induced polyclonal antibody synthesis in vitro, whereas intact protein A was a strong activator. It is concluded that the Fc binding part of protein A is not responsible for activation of polyclonal antibody synthesis.
- Subjects
CARRIER proteins; BINDING sites; IMMUNOGLOBULINS; B cells; CELL receptors; IMMUNOSPECIFICITY; ANTIGEN-antibody reactions
- Publication
Scandinavian Journal of Immunology, 1979, Vol 10, Issue 6, p593
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1979.tb01394.x