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- Title
Demonstration of High--Affinity Binding Sites for C3a Anaphylatoxin on Guinea--Pig Platelets.
- Authors
Becker, S.; Hadding, U.; Schorlemmer, H.U.; Bitter-Suermann, D.
- Abstract
³H-serotonin release from guinea-pig platelets was demonstrated to be the consequence of C3a binding to these cells. A Scatchard analysis of dose-response data of the 125I-C3a binding pattern to guinea-pig platelets pointed to the existence of binding sites with high and low affinity for the C3a molecule (HA and LA receptors). HA receptors are specific for C3a with intact C-terminal arginine, whereas C3adesargonly interacts with LA receptors. The release of serotonin may be induced by a combined reaction of C3a with HA receptors and LA receptors on the platelet membrane.
- Subjects
BINDING sites; BLOOD platelets; SEROTONIN; NEUROTRANSMITTERS; BIOCHEMISTRY
- Publication
Scandinavian Journal of Immunology, 1978, Vol 8, Issue 6, p551
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1978.tb00555.x