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- Title
Mechanisms of the H-2 Effect on Viral Leukemogenesis.
- Authors
Bubbers, J. F.; Blank, K. J.; Freedman, H. A.; Lilly, F.
- Abstract
Evidence has been gathered which supports the notion that two distinct but interacting mechanisms, controlled by loci mapping within the H-2 complex, influence Friend murine leukemia virus (FV) disease. One mechanism, controlled by a gene mapping in or close to H-2D, influences the capacity of the H-2D gene product to form molecular complexes with FV molecules in the plasma membrane of infected cells. Formation of a complex appears to provide a target antigen for syngeneic cytotoxic T-lymphocytes, to cause co-cupping of FV and H-2D antigens, to permit the selective inclusion of H-2D'' molecules into progeny Friend virions, to influence the long-term maintenance of virus production in vitro and, in conjunction with the second mechanism, to stimulate the generation of cytotoxic T-lymphocytes. This second mechanism is controlled by a gene in the H-2K or H-2I region, and, in the presence of an H-2/FV molecular complex immunogen, influences the generation of H-2 restricted cytotoxic T-lymphocytes and the rate of rejection of syngeneic FV-induced tumor cells.
- Subjects
LEUCOCYTES; CANCER cells; GENE mapping; CELL membranes; LYMPHOCYTES; ANTIGENS
- Publication
Scandinavian Journal of Immunology, 1977, Vol 6, Issue 5, p533
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1977.tb02117.x