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- Title
Cytotoxic Effect of Anti-H-2 and Anti-la Antisera on Human B and T Cells.
- Authors
Iványi, P.; Gyódi, E.; Györffy, Gy.; Pavljuková, H.; Ivasková, E.; Petrányi, Gy.
- Abstract
Anti-H-2 and anti-Ia alloimmune mouse antisera were tested by the microcytotoxicity test on human peripheral blood B- and T-cell preparations. Anti-H-2 antisera react by a higher titer and/or cytotoxicity scoring grade on B cells than on T cells. Anti-Ia antisera react practically only with B cells. It was assumed that anti-H-2 antisera contain two components. One component reacts specifically with certain HLA-A or -B-locus antigens or other closely linked gene products. The other component reacts predominantly or only with B-cell determinants; the specificity of the latter component has not yet been studied in sufficient detail.
- Subjects
IMMUNE serums; B cells; T cells; LYMPHOCYTES; ANTIGENS; IMMUNOGLOBULINS
- Publication
Scandinavian Journal of Immunology, 1977, Vol 6, Issue 5, p431
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1977.tb02100.x