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- Title
Alpha-fetoprotein.
- Abstract
The article presents information on alpha-fetoprotein (AFP). AFP is the first alpha-globulin to appear in mammalian serum during development and the dominating serum protein in early embryonic life. It reappears in the adult serum during certain pathological states, primarily in hepatocellular carcinoma. In the very early human embryo, AFP is probably the dominant serum protein, being replaced later by albumin, which it resembles with respect to many physicochemical properties. The biological function of human AFP is unknown. Rat AFP has a high affinity with estrogens, but human AFP does not have a similar binding activity.
- Subjects
ALPHA fetoproteins; BLOOD proteins; GLOBULINS; SERUM; LIVER cancer; ESTROGEN
- Publication
Scandinavian Journal of Immunology, 1976, Vol 5, p8
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1976.tb03154.x