We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Image analysis reveals differences in tumor multinucleations in Black and White patients with human papillomavirus-associated oropharyngeal squamous cell carcinoma.
- Authors
Koyuncu, Can F.; Nag, Reetoja; Lu, Cheng; Corredor, Germán; Viswanathan, Vidya S.; Sandulache, Vlad C.; Fu, Pingfu; Yang, Kailin; Pan, Quintin; Zhang, Zelin; Xu, Jun; Chute, Deborah J.; Thorstad, Wade L.; Faraji, Farhoud; Bishop, Justin A.; Mehrad, Mitra; Castro, Patricia D.; Sikora, Andrew G.; Thompson, Lester D.R.; Chernock, Rebecca D.
- Abstract
<bold>Background: </bold>Understanding biological differences between different racial groups of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) patients, who have differences in terms of incidence, survival, and tumor morphology, can facilitate accurate prognostic biomarkers, which can help develop personalized treatment strategies.<bold>Methods: </bold>This study evaluated whether there were morphologic differences between HPV-associated tumors from Black and White patients in terms of multinucleation index (MuNI), an image analysis-derived metric that measures density of multinucleated tumor cells within epithelial regions on hematoxylin-eosin images and previously has been prognostic in HPV-associated OPSCC patients. In this study, the authors specifically evaluated whether the same MuNI cutoff that was prognostic of overall survival (OS) and disease-free survival in their previous study, TTR , is valid for Black and White patients, separately. We also evaluated population-specific cutoffs, TB for Blacks and TW for Whites, for risk stratification.<bold>Results: </bold>MuNI was statistically significantly different between Black (mean, 3.88e-4; median, 3.67e-04) and White patients (mean, 3.36e-04; median, 2.99e-04), with p = .0078. Using TTR , MuNI was prognostic of OS in the entire population with hazard ratio (HR) of 1.71 (p = .002; 95% confidence interval [CI], 1.21-2.43) and in White patients with HR of 1.72 (p = .005; 95% CI, 1.18-2.51). Population-specific cutoff, TW , yielded improved HR of 1.77 (p = .003; 95% CI, 1.21-2.58) for White patients, whereas TB did not improve risk-stratification in Black patients with HR of 0.6 (p = .3; HR, 0.6; 95% CI, 0.2-1.80).<bold>Conclusions: </bold>Histological difference between White and Black patient tumors in terms of multinucleated tumor cells suggests the need for considering population-specific prognostic biomarkers for personalized risk stratification strategies for HPV-associated OPSCC patients.
- Subjects
PAPILLOMAVIRUSES; OROPHARYNGEAL cancer; HEAD &; neck cancer; RETROSPECTIVE studies; PROGNOSIS; PAPILLOMAVIRUS diseases; BENZOPYRANS; RESEARCH funding; FLUORESCENT dyes; SQUAMOUS cell carcinoma; DISEASE complications
- Publication
Cancer (0008543X), 2022, Vol 128, Issue 21, p3831
- ISSN
0008-543X
- Publication type
Article
- DOI
10.1002/cncr.34446