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- Title
XMEA: A New Hybrid Diamond Multielectrode Array for the In Situ Assessment of the Radiation Dose Enhancement by Nanoparticles.
- Authors
Nicolucci, Patricia; Gambaro, Guilherme; Araujo Silva, Kyssylla Monnyelle; Souza Lima, Iara; Baffa, Oswaldo; Pasquarelli, Alberto
- Abstract
This work presents a novel multielectrode array (MEA) to quantitatively assess the dose enhancement factor (DEF) produced in a medium by embedded nanoparticles. The MEA has 16 nanocrystalline diamond electrodes (in a cell-culture well), and a single-crystal diamond divided into four quadrants for X-ray dosimetry. DEF was assessed in water solutions with up to a 1000 µg/mL concentration of silver, platinum, and gold nanoparticles. The X-ray detectors showed a linear response to radiation dose (r2 ≥ 0.9999). Overall, platinum and gold nanoparticles produced a dose enhancement in the medium (maximum of 1.9 and 3.1, respectively), while silver nanoparticles produced a shielding effect (maximum of 37%), lowering the dose in the medium. This work shows that the novel MEA can be a useful tool in the quantitative assessment of radiation dose enhancement due to nanoparticles. Together with its suitability for cells' exocytosis studies, it proves to be a highly versatile device for several applications.
- Subjects
RADIATION doses; NANOPARTICLES; GOLD nanoparticles; SILVER nanoparticles; PLATINUM nanoparticles; DIAMONDS; EXOCYTOSIS; RAMAN scattering
- Publication
Sensors (14248220), 2024, Vol 24, Issue 8, p2409
- ISSN
1424-8220
- Publication type
Article
- DOI
10.3390/s24082409