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- Title
Regeneration of CNS axons back to their target following treatment of adult rat brain with chondroitinase ABC.
- Authors
Moon, Lawrence D. F.; Asher, Richard A.; Rhodes, Kate E.; Fawcett, James W.
- Abstract
Following CNS injury in the adult mammal, axon regeneration fails in scar regions containing a number of different chondroitin sulfate-bearing proteoglycans (CSPGs). Degradation of chondroitin sulfate using chondroitinase ABC reduces growth inhibition associated with many CSPGs. Here we demonstrate that it is possible to enhance CNS axon regeneration in the adult rat nigrostriatal tract following chondroitinase ABC degradation of chondroitin sulfate.
- Subjects
PROTEOGLYCANS; AXONS; REGENERATION (Biology); CENTRAL nervous system
- Publication
Nature Neuroscience, 2001, Vol 4, Issue 5, p465
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/87415