We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mother-to-Infant Transmission of GB Virus C/Hepatitis G Virus: The Role of High-Titered Maternal Viremia and Mode of Delivery.
- Authors
Lin, Ho-Hsiung; Kao, Jia-Horng; Yeh, Kuo-Yi; Liu, Ding-Ping; Chang, Mei-Hwei; Chen, Pei-Jer; Chen, Ding-Shinn
- Abstract
To study mother-to-infant transmission of GB virus C/hepatitis G virus (GBV-C/HGV), blood samples of infants born to carrier mothers were collected beginning 3 months after birth and were tested for GBV-C/HGV RNA until 1 year of age. Of 2046 mothers, 2.1% were positive for GBV-C/HGV RNA, and 25 of their infants were followed for a median of 12 months. Thirteen infants (52%) were viremic, and infection became persistent in all. Maternal GBV-C/HGV RNA levels of this group were >107 copies/mL. Nucleotide sequence comparison in 5 viremic mother-infant pairs revealed a homology of 93%–98.2%, and none delivered by elective cesarean section. In comparison, of the 12 uninfected infants' mothers, 10 had lower GBV-C/HGV RNA levels (mean, 5 × 104 copies/mL), and the remaining 2 high-titered mothers had elective cesarean section. Thus, high-titered maternal viremia and mode of delivery are closely associated with the mother-to-infant transmission of GBV-C/HGV to infants, and the infection usually becomes persistent.
- Publication
Journal of Infectious Diseases, 1998, Vol 177, Issue 5, p1202
- ISSN
0022-1899
- Publication type
Article