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- Title
Cytapheresis with a filter for selective removal of CD4[sup +] T cells in experimental autoimmune encephalomyelitis.
- Authors
Nakane, Shunya; Matsuo, Hidenori; Goto, Hirofumi; Yoshinaga-Matsumoto, Megumi; Ohtsuru, Izumi; Ichinose, Katsuhiro; Onodera, Hirokazu; Yoshida, Makoto; Shibuya, Noritoshi
- Abstract
Experimental autoimmune encephalomyelitis (EAE) is a major animal model of human multiple sclerosis (MS). CD4[sup +] T cells are thought to play a pivotal role in the pathogenesis of EAE and MS. In order to investigate the depletion of CD4[sup +] T cells from the systemic circulation as an effective strategy for the treatment of MS, we performed extracorporeal CD4[sup +] T cell adsorption, using a filter to which anti-CD4[sup +] antibody is immobilized as a ligand, in adoptively transferred EAE. Rats treated with CD4[sup +] T cell removal filter (CD4RF) exhibited milder clinical signs of EAE and earlier recovery than those receiving sham treatment. Moreover, the thymic cells from EAE rats treated with CD4RF exhibited a suppressed proliferative response and IFN-γ production to myelin basic protein. These results suggest that depletion of CD4[sup +] T cells from the systemic circulation by extracorporeal treatment is a potentially useful strategy for treatment of acute phase and relapsing MS.
- Subjects
ENCEPHALOMYELITIS; AUTOIMMUNITY; MULTIPLE sclerosis; CD4 antigen; T cells
- Publication
Multiple Sclerosis (13524585), 2003, Vol 9, Issue 6, p579
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1191/1352458503ms968oa