We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cerebrospinal fluid soluble programmed death‐ligand 1 is a useful prognostic biomarker in primary central nervous system lymphoma.
- Authors
Cheng, Chieh‐Lung; Yao, Chi‐Yuan; Huang, Po‐Hao; Yu, Chih‐Wei; Fang, Wei‐Quan; Chuang, Wen‐Hui; Wu, Shang‐Ju; Lin, Yu‐Jen; Hung, Yu‐Chin; Tsai, Cheng‐Hong; Yu, Shan‐Chi; Chou, Wen‐Chien; Tien, Hwei‐Fang
- Abstract
Summary: The increased expression of programmed death‐ligands 1 and 2 (PD‐L1 and PD‐L2, respectively) on tumour cells contributes to immune evasion, suggesting that these proteins are attractive therapeutic targets. This study aimed to evaluate the validity of cerebrospinal fluid (CSF) soluble PD‐L1 (sPD‐L1) and soluble PD‐L2 (sPD‐L2) as biomarkers for primary central nervous system lymphoma (PCNSL). We determined the CSF concentrations of sPD‐L1 and sPD‐L2 in 46 patients with PCNSL using enzyme‐linked immunosorbent assays (ELISAs). A control group comprised 153 patients with other brain tumours, inflammatory/infectious status, or neurodegenerative diseases. Only CSF sPD‐L1 levels were significantly higher in patients with PCNSL relative to the controls. CSF sPD‐L1 also exhibited superior overall discrimination performance compared to CSF sPD‐L2 in diagnosing PCNSL. Compared with patients with PCNSL with low CSF sPD‐L1 levels, more patients with high levels had high serum lactate dehydrogenase levels, leptomeningeal involvement, and deep‐brain involvement. Furthermore, CSF sPD‐L1 could predict poor survival in PCNSL but CSF sPD‐L2 could not. Intriguingly, CSF sPD‐L1 levels were correlated with disease status and their dynamic changes post treatment could predict time to relapse. In conclusion, this study identified CSF sPD‐L1 as a promising prognostic biomarker, indicating a therapeutic potential of PD‐L1 blockade in PCNSL.
- Subjects
PROGRAMMED death-ligand 1; CENTRAL nervous system; CEREBROSPINAL fluid; BIOMARKERS; ENZYME-linked immunosorbent assay; CENTRAL nervous system viral diseases
- Publication
British Journal of Haematology, 2023, Vol 201, Issue 1, p75
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.18598